Full module assessment covering all five inquiry questions: reproduction and continuity, exact DNA replication, polypeptide synthesis, genetic variation, and the strengths and limits of predicting inheritance patterns in populations.
~60 min20 MC | 4 Extended ResponseAll 19 Lessons40 marks total
Module Coverage
IQ1 - L01-05
Reproduction and Continuity
Sexual and asexual reproduction
Animal, plant, fungi, bacteria and protist reproduction
Mammalian reproduction
Agricultural manipulation of reproduction
IQ2 - L06-08
DNA Replication and Cell Division
Watson and Crick DNA model
Semiconservative replication
Mitosis and meiosis
Continuity and chromosome-number stability
IQ3 - L09-12
Gene Expression and Phenotype
DNA in prokaryotes and eukaryotes
Transcription and translation
Protein structure and function
Genotype, phenotype and environment
IQ4 - L13-16
Variation and Comparison
Crossing over, fertilisation and mutation
Mendelian and non-Mendelian inheritance
Punnett squares and pedigrees
Frequency data and SNP analysis
IQ5 - L17-19
Population Genetics Prediction
DNA sequencing versus profiling
Large-scale population data
Conservation, disease and human evolution
Strengths and limits of prediction
Section A - Multiple Choice (20 marks)
IQ1 - Reproduction and Continuity
Question 1
Which statement best compares sexual and asexual reproduction?
A Sexual reproduction always produces identical offspring, while asexual reproduction always produces variation
B Sexual reproduction usually increases variation, while asexual reproduction usually preserves successful genotypes
C Sexual reproduction is always faster than asexual reproduction
D Asexual reproduction never occurs in plants
Question 2
What is a major advantage of internal fertilisation in animals?
A It always produces more gametes than external fertilisation
B It eliminates the need for parental investment
C Gametes are better protected from environmental loss or drying
D It only occurs in aquatic species
Question 3
Which process is an example of plant asexual reproduction?
A Pollination
B Fertilisation of the ovule
C Seed formation after meiosis
D Vegetative propagation by runners
Question 4
What is the role of hCG early in pregnancy?
A It helps maintain the corpus luteum and progesterone production
B It triggers lactation immediately after birth
C It causes sperm production in the testes
D It directly causes implantation by digesting the uterine wall
IQ2 - Replication and Cell Division
Question 5
Which statement describes semiconservative DNA replication?
A Each new DNA molecule is made entirely of newly synthesised strands
B One daughter cell keeps all the original DNA
C Each new DNA molecule contains one original strand and one newly synthesised strand
D DNA replication only occurs during meiosis II
Question 6
Why is meiosis essential for sexual reproduction?
A It doubles chromosome number in gametes
B It halves chromosome number so fertilisation can restore diploid number
C It prevents any variation in offspring
D It is the same process as mitosis
Question 7
What is a key role of mitosis in multicellular organisms?
A Production of haploid gametes
B Exchange of DNA between homologous chromosomes
C Reduction of chromosome number across generations
D Growth and repair while maintaining chromosome number
Question 8
What is the main source of new alleles?
A Mutation
B Crossing over only
C Random fertilisation only
D Mitosis
IQ3 - Gene Expression and Phenotype
Question 9
What is the main role of mRNA in gene expression?
A To carry amino acids to the ribosome
B To replicate DNA during S phase
C To carry a temporary copy of the gene's code for translation
D To catalyse peptide bond formation directly without a ribosome
Question 10
Which molecule has an anticodon and carries an amino acid?
A DNA
B tRNA
C mRNA
D Ribosomal protein
Question 11
Why can a change in DNA sequence affect phenotype?
A Because it can alter protein structure or function
B Because it always changes chromosome number
C Because phenotype never depends on proteins
D Because all proteins are identical
Question 12
Why can genotype not always predict phenotype with certainty?
A Because genes never influence phenotype
B Because meiosis prevents phenotype expression
C Because all alleles are always expressed equally
D Because environment and other biological factors can influence expression
IQ4 - Variation and Comparison
Question 13
Which process reshuffles existing alleles during meiosis?
A Crossing over
B Translation
C Binary fission
D Implantation
Question 14
Which clue most strongly supports X-linked recessive inheritance?
A The trait can skip generations
B Both males and females can be affected
C Unaffected parents can have an affected child
D There is no father-to-son transmission of the affected allele
Question 15
Which statement best describes co-dominance?
A The heterozygote is always intermediate
B Both alleles are fully expressed in the heterozygote
C One allele disappears in the heterozygote
D The gene exists on multiple chromosomes
Question 16
What is a major limitation of using one SNP only to compare populations?
A One SNP always determines every phenotype
B One SNP cannot differ between groups
C One marker alone may not represent overall genomic similarity
D One SNP removes the need for larger data sets
IQ5 - Population Genetics Prediction
Question 17
What is the key difference between DNA sequencing and DNA profiling?
A Sequencing determines base order, while profiling compares selected DNA patterns
B Profiling determines the full genome sequence, while sequencing compares markers only
C They are identical technologies with identical outputs
D Neither can be used in population studies
Question 18
Why are large-scale collaborative data sets valuable in population genetics?
A They remove all uncertainty from conclusions
B They guarantee exact predictions for every individual
C They eliminate environmental influence on phenotype
D They reveal broader trends and relationships across many samples
Question 19
Which prediction is most reliable in population genetics?
A The exact future phenotype of every individual
B Broad risk, relatedness and allele-distribution trends
C The exact environmental conditions of future populations
D The exact mutation history of all future generations
Question 20
Why is Module 5 a foundation for Module 6?
A Because Module 6 ignores heredity
B Because Module 5 proves mutation never changes patterns
C Because Module 5 explains heredity and prediction, which Module 6 extends into mutation and genetic change
D Because Module 6 is only a repeat of Module 5 with no new content
Section B - Extended Response (20 marks)
Question 21
Explain how reproduction and cell-division processes ensure both continuity of species and genetic variation.
5 marks
Reproduction ensures continuity of species by transferring DNA from one generation to the next. Mitosis preserves chromosome number and supports growth, repair and asexual reproduction. Meiosis halves chromosome number so fertilisation can restore diploid number. Genetic variation arises through crossing over, independent assortment, random fertilisation and mutation, so species continuity is maintained while populations also contain variation.
Question 22
Explain how DNA is expressed to produce phenotype, and why phenotype cannot always be predicted from genotype alone.
5 marks
DNA is expressed through transcription, where a gene is copied into mRNA, and translation, where ribosomes use codons and tRNA to assemble a polypeptide. Protein structure and function contribute to phenotype by affecting enzymes, transport, receptors and structural roles. However, phenotype cannot always be predicted from genotype alone because environment, gene interactions and variation in expression can influence the final phenotype.
Question 23
Compare how inheritance patterns can be modelled at the family level and analysed at the population level.
5 marks
At the family level, inheritance can be modelled using Punnett squares and pedigrees to predict genotype probabilities and infer autosomal, sex-linked or non-Mendelian patterns. At the population level, frequency data, SNP analysis, sequencing and profiling are used to identify broader trends in allele distribution, relatedness and inherited risk. The main difference is that family-level models focus on probable outcomes within a pedigree, while population-level analysis focuses on trends and frequencies across groups.
Question 24
Evaluate the statement: "Population genetics can predict inheritance patterns accurately." In your response, include both strengths and limitations.
5 marks
Population genetics can predict inheritance patterns accurately when the prediction is about broad trends such as risk patterns, relatedness and allele distribution in groups. Sequencing, profiling and large collaborative data sets strengthen these inferences. However, exact individual outcomes remain uncertain because phenotype is influenced by environment, interacting genes, mutation and future population change. Therefore, the statement is partly correct only if "accurately" is understood as trend-level prediction rather than complete certainty for every individual case.
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